AIM ImmunoTech Inc., an immuno-pharmaceutical company based in Ocala, Florida, focuses on discovering and advancing treatments for a diverse array of cancers, viral infections, and immune system disorders across the United States. Its primary drug offerings include Ampligen (rintatolimod), a large macromolecular double-stranded ribonucleic acid compound developed for chronic fatigue syndrome, and Alferon N Injection (Interferon alfa), a purified, naturally derived, multi-species alpha interferon prescribed for genital warts. Furthermore, Ampligen is currently undergoing investigation for its potential application in treating pancreatic, renal cell, malignant melanoma, non-small cell lung, ovarian, breast, colorectal, and prostate cancers, as well as myalgic encephalomyelitis, Hepatitis B, HIV, COVID-19, and post-COVID conditions. The company, originally incorporated in 1966, was formerly known as Hemispherx Biopharma, Inc. until its name change in August 2019.
AIM ImmunoTech’s Strategy to Address Immune Resistance in Pancreatic Cancer Featured in BioTuesdays
AIM ImmunoTech spotlighted a BioTuesdays feature on its strategy to use Ampligen as a maintenance therapy in metastatic pancreatic cancer following first-line chemotherapy.
Final dosing is complete in the Phase 2 DURIPANC trial pairing Ampligen with AstraZeneca's Imfinzi, with primary and secondary endpoints still pending.
The feature also cites exploratory Named Patient Program data: in 39 Dutch patients with an NLR below 4.5, median overall survival was 34.8 months from FOLFIRINOX start, though these uncontrolled observations do not establish efficacy.