Context Therapeutics Inc., a biopharmaceutical company, develops products for the treatment of solid tumors. Its lead program candidate is CTIM-76, an anti-Claudin 6 (CLDN6) x anti-CD3 bispecific antibody that is intended to redirect T-cell-mediated lysis toward malignant cells expressing CLDN6. The company has a collaboration and licensing agreement with Integral Molecular, Inc. for the development of a CLDN6 bispecific monoclonal antibody for cancer therapy. The company was incorporated in 2015 and is headquartered in Philadelphia, Pennsylvania.
Context Therapeutics Announces First Patient Dosed in Phase 1 Trial of CT-202
Context Therapeutics dosed the first patient in the Phase 1 trial of CT-202, a Nectin-4 x CD3 T cell engaging bispecific antibody being developed for solid tumors.
The open-label, dose-escalation study (NCT07545122) is evaluating CT-202 as a monotherapy in patients with Nectin-4-expressing recurrent, unresectable or metastatic refractory/resistant urothelial, colorectal and triple-negative breast cancers.
Management expects initial Phase 1a data in the second half of 2027, making this an early pipeline-validation step rather than a near-term catalyst for the clinical-stage biotech.