Cocrystal Pharma, Inc. (COCP) is a biotechnology firm dedicated to researching and advancing antiviral treatments for severe and/or persistent viral illnesses. The company leverages structure-based technologies to create new antiviral medications, primarily focusing on infections caused by the hepatitis C virus (HCV), influenza, coronaviruses, and noroviruses. Its current pipeline includes CC-31244, a non-nucleoside polymerase inhibitor for HCV, which has successfully completed Phase IIa clinical trials. Additionally, CC-42344, a PB2 inhibitor designed to combat influenza, is currently undergoing preclinical development. Cocrystal Pharma is also actively pursuing the development of non-nucleoside polymerase inhibitors to address norovirus infections. The company maintains strategic alliances, including a research and licensing collaboration with Merck Sharp & Dohme Corp. for the discovery and development of proprietary influenza A/B antiviral agents. It also holds a licensing agreement with the Kansas State University Research Foundation, aimed at advancing antiviral compounds for norovirus and coronavirus infections. Furthermore, Cocrystal Pharma engages in drug discovery collaborations with both HitGen and InterX Inc. The company's operations are headquartered in Bothell, Washington.
Cocrystal Pharma Announces Last Subject Dosed in Phase 1b Human Challenge Study Evaluating CDI-988 for Norovirus Prevention and Treatment
Cocrystal Pharma dosed the last subject in its Phase 1b human challenge study (NCT07198139) evaluating CDI-988 as both a preventive and treatment for norovirus, with no serious adverse events reported to date.
The randomized, double-blind, placebo-controlled trial is being run at Emory University School of Medicine, dosing healthy subjects ages 18-49 infected with the GII.2 Snow Mountain Virus strain at the 1200 mg dose established as safe in an earlier Phase 1 study in Australia.
Preliminary efficacy results are expected in late 2026 or early 2027, and management positions CDI-988 as a potential first-in-class oral antiviral targeting a disease with an estimated 685 million global cases and $60 billion in annual economic impact.