Evommune, Inc. is a United States-based clinical-stage biotechnology company dedicated to advancing novel therapeutic solutions. Their primary focus lies in addressing the underlying mechanisms of chronic inflammatory diseases. Initial clinical development efforts are concentrated on conditions such as chronic spontaneous urticaria, atopic dermatitis, and ulcerative colitis. The company's investigational portfolio features EVO756, which is being developed for the treatment of chronic spontaneous urticaria (CSU) and atopic dermatitis (AD), and EVO301, intended for atopic dermatitis (AD) and ulcerative colitis (UC). Established in 2020, Evommune operates from its headquarters in Palo Alto, California.
Evommune Presents Late-Breaking Phase 2a Proof-of-Concept Data Evaluating EVO301 in Atopic Dermatitis at European Academy of Dermatology and Venereology Congress
Evommune presented late-breaking Phase 2a proof-of-concept data for EVO301 in moderate-to-severe atopic dermatitis at the EADV 2026 Congress, meeting the primary endpoint with a 55% LS-mean EASI reduction at Week 12 versus 22% on placebo (p<0.01).
Responses deepened over time despite only two IV doses, with EASI-75 of 29% vs 9% placebo at Week 12 and a placebo-like safety profile including no conjunctivitis.
Biomarker data confirmed broad Th2, Th1, and Th17/22 pathway modulation, supporting IL-18 inhibition as a novel AD mechanism, with a subcutaneous Phase 2b dose-ranging trial planned for mid-2027.