IGC Pharma, Inc. operates as a pharmaceutical firm, currently in the clinical development phase, dedicated to pioneering novel treatments for Alzheimer's, a debilitating condition. The company's pipeline includes two experimental drug candidates aimed at this disease: IGC-AD1, which is presently undergoing a Phase 2 clinical study for addressing agitation associated with Alzheimer's-related dementia, and TGR-63, which is still in its preclinical stage. Beyond its therapeutic development efforts, IGC Pharma also explores the application of artificial intelligence (AI) to advance Alzheimer's research. Established on April 29, 2005, by Ram Mukunda, the company maintains its principal office in Potomac, Maryland.
IGC Pharma Completes Enrollment in Phase 2 CALMA Alzheimer's Trial; Topline Results Expected Q4 2026
IGC Pharma completed enrollment in its Phase 2 CALMA trial of IGC-AD1 for agitation in Alzheimer's dementia, with 168 participants randomized including planned over-enrollment.
Final participant dosing is expected in early November, with topline results targeted for Q4 2026 after database lock and unblinding.
The Data Safety Monitoring Committee has recommended the trial continue without modification at each periodic review, with no treatment-related serious adverse events identified to date.
The primary endpoint is change in agitation from baseline to week six on the Cohen-Mansfield Agitation Inventory, tested across clinical sites in the United States and Canada.