Korro Bio, Inc., a biopharmaceutical firm based in Cambridge, Massachusetts, is dedicated to exploring, advancing, and bringing to market genetic therapeutics. These treatments are formulated through RNA editing technology, aiming to address a wide array of medical conditions, encompassing both uncommon and widespread diseases.
Korro Announces First Cohort Dosed in Phase 1/2 Clinical Trial (ANCHOR) for KRRO-121
Korro Bio dosed the first cohort of healthy volunteers in its Phase 1/2 ANCHOR trial of KRRO-121, a GalNAc-conjugated RNA-editing oligonucleotide for hyperammonemia in urea cycle disorders and hepatic encephalopathy.
The first cohort received a single 2mg/kg dose; the trial is enrolling in Australia with Part 1 (SAD/MAD) in up to 50 healthy volunteers and Part 2 in up to 15 UCD patients across all genotypes.
Dosing of UCD patients is expected in the first half of 2027 with an interim readout in the second half of 2027, making this an early safety-stage milestone rather than a near-term catalyst.