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Lyell Immunopharma, Inc., a T cell reprogramming company, engages in developing T cell therapies for patients with solid tumors. The company develops therapies using technology platforms, such as Gen-R, an ex vivo genetic reprogramming technology to overcome T cell exhaustion; and Epi-R, an ex vivo epigenetic reprogramming technology to generate population of T cells with durable stemness. Its pipeline includes LYL797, a T cell product candidate for the treatment of non-small cell lung cancer and triple negative breast cancers; LYL845, that targets multiple solid tumors; and NY-ESO-1 for synovial sarcoma and other solid tumor indications. The company entered into research and development collaboration and license agreement with GlaxoSmithKline for NY-ESO-1 program. Lyell Immunopharma, Inc. was incorporated in 2018 and is headquartered in South San Francisco, California.
Lyell Immunopharma presented updated safety data for ronde-cel in 108 patients with relapsed or refractory large B-cell lymphoma at the EHA 2026 Congress.
The data showed no Grade 3 or higher Cytokine Release Syndrome (CRS) events and low rates of Grade 3 or higher Immune Effector Cell-Associated Neurotoxicity Syndrome (ICANS), supporting the potential for outpatient administration.
Translational insights highlighted the biological basis for durable responses, including enhanced memory potential of cytotoxic effector cells via CD62L+ enrichment and dual-targeting of CD19/CD20.
The company expects updated data from the pivotal PiNACLE trial in the second half of 2026, with a BLA submission targeted for the second half of 2027.