Marker Therapeutics, Inc. is a clinical-stage immuno-oncology company focused on discovering and bringing to market a variety of T cell-based immunotherapies and peptide-based vaccines. These cutting-edge treatments are engineered to address both blood cancers (hematological malignancies) and solid tumor conditions across the United States. A cornerstone of their approach is the proprietary MultiTAA-specific T cell technology. This method involves producing T cells that are not genetically modified but are specifically designed to target tumors. These specialized T cells can identify multiple antigens associated with tumors, allowing them to effectively eliminate cancer cells that express these markers. Marker Therapeutics' MultiTAA-specific T cell therapies encompass patient-derived (autologous) T cells for treating lymphoma and various solid tumors, as well as donor-derived (allogeneic) T cells for acute myeloid leukemia and acute lymphoblastic leukemia. They also provide "off-the-shelf" solutions applicable to a range of diseases. In addition to T cell therapies, the company is advancing peptide-based immunotherapeutic vaccines. This pipeline includes TPIV100/110, developed to combat breast and ovarian cancer cells, and TPIV200, which is currently undergoing Phase 2 clinical trials for the treatment of breast and ovarian cancers. Founded in 1999, Marker Therapeutics maintains its headquarters in Houston, Texas.
Marker Therapeutics Highlights Expanded Manufacturing Support of CDMO Partner Following Formation of Kincellis Advanced Therapies
Marker Therapeutics highlighted expanded manufacturing support for its lead program MT-601 (neldaleucel) after its CDMO partner Cellipont Bioservices combined with Kincell Bio to form Kincellis Advanced Therapies.
Kincellis brings roughly 140,000 square feet of development and manufacturing infrastructure with 16 operational, qualified GMP suites across three U.S. locations, which Marker says strengthens and de-risks the manufacturing foundation for MT-601 as it advances toward later-stage clinical development.
MT-601 is being studied in the Phase 1 APOLLO trial (NCT05798897) in lymphoma patients who relapsed after or are not candidates for anti-CD19 CAR-T therapy; previously reported dose-escalation data showed a 66% objective response rate among 12 non-Hodgkin lymphoma patients, with 50% achieving complete remission.