Palisade Bio, Inc., a clinical-stage biopharmaceutical company, engages in developing oral phosphodiesterase-4 inhibitor prodrugs designed for targeted delivery to the terminal ileum and colon in the United States. Its lead clinical product candidate includes PALI-2108, which is in phase 1b clinical trial to treat patients with inflammatory bowel disease, including ulcerative colitis and Fibrostenotic Crohn’s disease. The company has a research collaboration and license agreement with Giiant Pharma, Inc. for the development, manufacture, and commercialization of its compounds; license agreement with the Regents of the University of California for sole purpose of maintaining the Newsoara Co-Development; and a co-development and distribution agreement with Newsoara Biopharma Co., Ltd. The company was founded in 2001 and is headquartered in Denver, Colorado.
Palisade Bio to Present Clinical and Translational Data for PALI-2108 in Ulcerative Colitis and Crohn’s Disease at UEG Week 2026
Palisade Bio's lead program PALI-2108 will be featured in four presentations at United European Gastroenterology (UEG) Week 2026, taking place October 17-20 in Barcelona.
The lineup includes an oral presentation of Phase 1b findings in fibrostenotic Crohn's disease showing early endoscopic improvement and PDE4 target engagement, plus three moderated posters covering gut-targeted exposure, rapid clinical response in ulcerative colitis, and a response-predicting biomarker.
PALI-2108 is being advanced into Phase 2 trials in both ulcerative colitis and Crohn's disease as a once-daily oral PDE4 inhibitor prodrug.