PepGen Inc., a clinical-stage biotechnology company, develops oligonucleotide therapeutics for the treatment of severe neuromuscular and neurologic diseases in the United States. The company engages in the development of PGN-EDODM1, an EDO peptide-conjugated PMO, which is in Phase 2 clinical trial for the treatment of myotonic dystrophy type 1; and FREEDOM2-DM1, which is in Phase 2 for the treatment of myotonic dystrophy type 1. It is also involved in FREEDOM-OLE, an open label expansion study. The company was founded in 2018 and is based in Boston, Massachusetts.
PepGen Reports Second Quarter 2026 Financial Results and Recent Corporate Highlights
PepGen reported Q2 2026 financial results, highlighting a net loss of $0.26 per share and a cash position of $117.2 million, which funds operations into Q4 2027.
Clinically, the DSMB recommended advancing the FREEDOM2 trial to the 12.5 mg/kg cohort and escalating the OLE study dose to 10 mg/kg, citing positive safety data.
The 10 mg/kg cohort is fully enrolled with data expected in November, while results from the higher dose cohort are anticipated in the first half of 2027.