PMV Pharmaceuticals, Inc. operates as a precision oncology company focused on discovering and developing both small molecule and tumor-agnostic therapies to address p53 mutations in cancer patients. Their leading experimental drug, PC14586, is a small molecule designed to correct the p53 protein specifically when it contains the Y220C mutation, thereby restoring its natural, functional state. The company is also progressing a pipeline of other programs targeting various mutant p53 forms, including Wild-type p53 Induced-Phosphatase, R282W, R273H, and other prevalent p53 hotspot mutations. Originally known as PJ Pharmaceuticals, Inc., the firm rebranded to PMV Pharmaceuticals, Inc. in July 2013. The company was founded in 2013 and has its main operational base in Cranbury, New Jersey.
PMV Pharmaceuticals Appoints Matt Eckler, Ph.D., to Board of Directors
PMV Pharmaceuticals appointed Matt Eckler, Ph.D., a Principal at Samsara BioCapital, to its Board of Directors, adding more than two decades of healthcare investing experience.
The appointment follows completion of enrollment in the Phase 2 monotherapy portion of the pivotal PYNNACLE trial of rezatapopt, with an NDA submission for accelerated approval in TP53 Y220C platinum-resistant/refractory ovarian cancer planned for Q1 2027.
Rezatapopt holds FDA Fast Track and Orphan Drug designations; the board addition is a governance update ahead of the commercialization push rather than a program change.