SCYNEXIS, Inc. is a biotechnology company, which engages in the development of novel oral and intravenous triterpenoid antifungal for the treatment of several fungal infections, including vulvovaginal candidiasis, invasive aspergillosis, invasive candidiasis, and refractory invasive fungal infections. The company was founded by Scot Kevin Huber, Terry Eugene Marquardt, Pierre Bernard Jacques Monnet, Russell J. Outcalt, and Yves Joseph Ribeill on November 4, 1999 and is headquartered in Jersey City, NJ.
SCYNEXIS Announces Phase 1 Study Results for SCY-770, a Novel, Highly Selective, Oral Direct AMPK Activator for the Treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD)
SCYNEXIS completed a Phase 1 study of SCY-770, a first-in-class oral direct AMPK activator for ADPKD, showing the drug was well tolerated with a favorable safety profile at higher doses than previously evaluated.
The study enrolled 25 healthy participants across three cohorts with doses up to 750 mg once daily or 500 mg twice daily; safety was consistent with prior clinical experience across roughly 300 cumulative participants.
The Phase 2 proof-of-concept study in ADPKD patients remains on track to initiate in Q4 2026, with SCY-770 holding FDA Orphan Drug Designation for the indication.