Silexion Therapeutics LTD is a biopharmaceutical company specializing in the discovery and advancement of RNA interference (RNAi)-based cancer therapies and their associated delivery systems, with a focus on treating aggressive solid tumors. The company's strategy for addressing these tumors relies on its proprietary LODER delivery platform. Its product pipeline features several key candidates: SiG12D-LODER, which has progressed through both preclinical studies and an open-label Phase I clinical trial for pancreatic cancer; Prostate-LODER, currently undergoing preclinical evaluation for prostate cancer; and GBM-LODER, also in preclinical development, targeting Glioblastoma Multiforme, a highly malignant primary brain tumor. Founded in 2008, Silexion Therapeutics is headquartered in Jerusalem, Israel.
Silexion Therapeutics Reports Second Quarter 2026 Financial Results and Provides Business Update
Silexion advanced its lead asset SIL204 into an active Phase 2/3 clinical program for locally advanced pancreatic cancer, initiating the trial at Tel Aviv Sourasky Medical Center following regulatory approvals in Israel and Germany.
To support the program and restore Nasdaq compliance, the company executed a 1-for-10 reverse stock split and closed a public offering raising approximately $2.5 million in gross proceeds.
Financial results for the second quarter showed a net loss of $3.6 million, driven by a 120% increase in R&D expenses to $2.2 million as the company prepared for clinical execution.