Xenetic Biosciences, Inc. operates as a biopharmaceutical firm, primarily concentrating on the development of XCART. This cutting-edge personalized chimeric antigen receptor T cell (CAR T) platform is specifically engineered to identify and attack distinct tumor neoantigens found in individual patients. Beyond this specialized area, the company actively engages in the discovery, investigation, and creation of advanced biologic medicines and cancer treatments. A significant part of its cell-based therapeutic endeavors involves therapies designed to target the B-cell receptor on the exterior of malignant tumor cells in specific patients, with the aim of addressing B-cell lymphomas. Furthermore, Xenetic capitalizes on its proprietary drug delivery technology, PolyXen, through strategic alliances with various biotechnology and pharmaceutical enterprises. The company has established important collaborative agreements with partners including Takeda Pharmaceutical Co. Ltd., Serum Institute of India Limited, PJSC Pharmsynthez, and SynBio LLC. Xenetic Biosciences, Inc. has its headquarters located in Framingham, Massachusetts.
Xenetic Biosciences and Santersus AG Announce Definitive Share Exchange Agreement to Create Global Leader in NET-Targeting Therapeutics
Xenetic Biosciences (NASDAQ: XBIO) has signed a definitive all-stock share exchange agreement to acquire Santersus AG, with the combined company to be renamed Santersus Bio, Inc. and trade on Nasdaq under a new ticker, SNTS.
On a pro forma fully diluted basis, current Xenetic equity holders will own approximately 15.0% of the combined company while Santersus holders receive about 85.0%, subject to adjustment based on Xenetic's net cash at closing. The deal is expected to close in Q4 2026, pending Xenetic stockholder approval, Nasdaq listing of the new shares, and effectiveness of a resale S-1.
The combined pipeline comprises four first-in-class NET-targeting programs, including pivotal-stage NucleoCapture studies in sepsis and systemic lupus erythematosus — each with FDA Breakthrough Device Designation — plus a Phase 1b study pairing Xenetic's DNase with anti-CD19 CAR-T cells in large B-cell lymphoma.
Santersus CEO James Ladtkow will lead the combined company with a board of eight split six Santersus nominees to two Xenetic nominees, and key equity holders, directors and officers have signed 180-day post-closing lock-ups.