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Xenetic Biosciences, Inc., a biopharmaceutical company, focuses on advancing XCART, a personalized chimeric antigen receptor T cell (CAR T) platform technology engineered to target patient-specific tumor neoantigens. The company engages in the discovery, research, and development of biologic drugs and oncology therapeutics. It advances cell-based therapeutics targeting the B-cell receptor on the surface of an individual patient's malignant tumor cells for the treatment of B-cell lymphomas. It is also leveraging PolyXen, its proprietary drug delivery platform, by partnering with biotechnology and pharmaceutical companies. It has collaboration agreements with Takeda Pharmaceutical Co. Ltd., Serum Institute of India Limited, PJSC Pharmsynthez, and SynBio LLC. Xenetic Biosciences, Inc. is headquartered in Framingham, Massachusetts.
Xenetic Biosciences announced that its partner PeriNess received regulatory approval from the Israeli Ministry of Health to conduct an exploratory clinical study of DNase I in combination with anti-CD19 CAR T cells.
The investigator-initiated study will treat 12 patients with large B-cell lymphoma at the Tel-Aviv Sourasky Medical Center, aiming to evaluate efficacy and biomarker responses in patients with stable or progressive disease.
This follows strong preclinical data showing that DNase I enhances CAR T cell expansion and persistence by degrading cell-free chromatin and neutrophil extracellular traps in the tumor microenvironment.